Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Identifieur interne : 000D75 ( Main/Exploration ); précédent : 000D74; suivant : 000D76Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Auteurs : Hui Ren [République populaire de Chine] ; Hua Guo [République populaire de Chine] ; Asmitananda Thakur [République populaire de Chine] ; Shuo Zhang [République populaire de Chine] ; Ting Wang [République populaire de Chine] ; Yiqian Liang [République populaire de Chine] ; Puyu Shi [République populaire de Chine] ; Lei Gao [République populaire de Chine] ; Feng Liu [République populaire de Chine] ; Jing Feng [République populaire de Chine] ; Tianjun Chen [République populaire de Chine] ; Tian Yang [République populaire de Chine] ; Dong Shang [République populaire de Chine] ; Johnson J. Liu [Australie] ; Feng Xu [République populaire de Chine] ; Mingwei Chen [République populaire de Chine]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Descripteurs français
- KwdFr :
- Aminopyridines (pharmacologie), Animaux, Antienzymes (pharmacologie), Antinéoplasiques (pharmacologie), Autophagie (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Chloroquine (pharmacologie), Humains, Inhibiteurs de protéines kinases (pharmacologie), Lignée cellulaire tumorale, Morpholines (pharmacologie), Protéines proto-oncogènes c-akt (antagonistes et inhibiteurs), Souris, Système de signalisation des MAP kinases (), Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (anatomopathologie).
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- antagonistes et inhibiteurs : Protéines proto-oncogènes c-akt.
- pharmacologie : Aminopyridines, Antienzymes, Antinéoplasiques, Chloroquine, Inhibiteurs de protéines kinases, Morpholines.
- Animaux, Autophagie, Humains, Lignée cellulaire tumorale, Souris, Système de signalisation des MAP kinases, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- Aminopyridines (pharmacology), Animals, Antineoplastic Agents (pharmacology), Autophagy (drug effects), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Tumor, Chloroquine (pharmacology), Enzyme Inhibitors (pharmacology), Humans, Lung Neoplasms (pathology), MAP Kinase Signaling System (drug effects), Mice, Morpholines (pharmacology), Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors (pharmacology), Proto-Oncogene Proteins c-akt (antagonists & inhibitors), Xenograft Model Antitumor Assays.
- MESH :
- chemical , antagonists & inhibitors : Proto-Oncogene Proteins c-akt.
- chemical , pharmacology : Aminopyridines, Antineoplastic Agents, Chloroquine, Enzyme Inhibitors, Morpholines, Protein Kinase Inhibitors.
- drug effects : Autophagy, MAP Kinase Signaling System.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Animals, Cell Line, Tumor, Humans, Mice, Phosphoinositide-3 Kinase Inhibitors, Xenograft Model Antitumor Assays.
Abstract
NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM120 potently induced elevation of autophagosome-bound type II LC3 (LC3-II) protein, predominantly in cell lines insensitive to BKM120, thereby inducing autophagy. The presence of lysosomal protease inhibitor chloroquine further enhanced the levels of LC3-II. BKM120 combined with chloroquine, enhanced growth-inhibitory effects including induction of apoptosis, suggesting that autophagy is a protective mechanism counteracting BKM120's growth-inhibitory activity. Interestingly, BKM120 increased p-ERK1/2 levels. When blocking the activation of this signaling with MEK inhibitors or with knockdown of ERK1/2, the ability of BKM120 to increase LC3-II was attenuated and the growth-inhibitory effects including induction of apoptosis were accordingly enhanced, suggesting that the MEK/ERK activation contributes to BKM120-induced authophagy. In mouse xenograft model, we also found that the combination of BKM120 and PD0325901 synergistically suppressed cell growth in human lung cancer cells. Thus, the current study not only reveals mechanisms accounting for BKM120-induced autophagy, but also suggests an alternative method to enhance BKM120's therapeutic efficacy against non-small cell lung cancer(NSCLC) by blocking autophagy with either a lysosomal protease inhibitor or MEK inhibitor.
DOI: 10.18632/oncotarget.11645
PubMed: 27572309
Affiliations:
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Le document en format XML
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Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Feng" sort="Liu, Feng" 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of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. 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wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Thakur, Asmitananda" sort="Thakur, Asmitananda" uniqKey="Thakur A" first="Asmitananda" last="Thakur">Asmitananda Thakur</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ting" sort="Wang, Ting" uniqKey="Wang T" first="Ting" last="Wang">Ting Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Yiqian" sort="Liang, Yiqian" uniqKey="Liang Y" first="Yiqian" last="Liang">Yiqian Liang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Puyu" sort="Shi, Puyu" uniqKey="Shi P" first="Puyu" last="Shi">Puyu Shi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Jing" sort="Feng, Jing" uniqKey="Feng J" first="Jing" last="Feng">Jing Feng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Tianjun" sort="Chen, Tianjun" uniqKey="Chen T" first="Tianjun" last="Chen">Tianjun Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Tian" sort="Yang, Tian" uniqKey="Yang T" first="Tian" last="Yang">Tian Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. Liu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name><affiliation wicri:level="1"><nlm:affiliation>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopyridines (pharmacology)</term><term>Animals</term><term>Antineoplastic Agents (pharmacology)</term><term>Autophagy (drug effects)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Cell Line, Tumor</term><term>Chloroquine (pharmacology)</term><term>Enzyme Inhibitors (pharmacology)</term><term>Humans</term><term>Lung Neoplasms (pathology)</term><term>MAP Kinase Signaling System (drug effects)</term><term>Mice</term><term>Morpholines (pharmacology)</term><term>Phosphoinositide-3 Kinase Inhibitors</term><term>Protein Kinase Inhibitors (pharmacology)</term><term>Proto-Oncogene Proteins c-akt (antagonists & inhibitors)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aminopyridines (pharmacologie)</term><term>Animaux</term><term>Antienzymes (pharmacologie)</term><term>Antinéoplasiques (pharmacologie)</term><term>Autophagie ()</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Chloroquine (pharmacologie)</term><term>Humains</term><term>Inhibiteurs de protéines kinases (pharmacologie)</term><term>Lignée cellulaire tumorale</term><term>Morpholines (pharmacologie)</term><term>Protéines proto-oncogènes c-akt (antagonistes et inhibiteurs)</term><term>Souris</term><term>Système de signalisation des MAP kinases ()</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Tumeurs du poumon (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminopyridines</term><term>Antineoplastic Agents</term><term>Chloroquine</term><term>Enzyme Inhibitors</term><term>Morpholines</term><term>Protein Kinase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines proto-oncogènes c-akt</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>MAP Kinase Signaling System</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminopyridines</term><term>Antienzymes</term><term>Antinéoplasiques</term><term>Chloroquine</term><term>Inhibiteurs de protéines kinases</term><term>Morpholines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Humans</term><term>Mice</term><term>Phosphoinositide-3 Kinase Inhibitors</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Souris</term><term>Système de signalisation des MAP kinases</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM120 potently induced elevation of autophagosome-bound type II LC3 (LC3-II) protein, predominantly in cell lines insensitive to BKM120, thereby inducing autophagy. The presence of lysosomal protease inhibitor chloroquine further enhanced the levels of LC3-II. BKM120 combined with chloroquine, enhanced growth-inhibitory effects including induction of apoptosis, suggesting that autophagy is a protective mechanism counteracting BKM120's growth-inhibitory activity. Interestingly, BKM120 increased p-ERK1/2 levels. When blocking the activation of this signaling with MEK inhibitors or with knockdown of ERK1/2, the ability of BKM120 to increase LC3-II was attenuated and the growth-inhibitory effects including induction of apoptosis were accordingly enhanced, suggesting that the MEK/ERK activation contributes to BKM120-induced authophagy. In mouse xenograft model, we also found that the combination of BKM120 and PD0325901 synergistically suppressed cell growth in human lung cancer cells. Thus, the current study not only reveals mechanisms accounting for BKM120-induced autophagy, but also suggests an alternative method to enhance BKM120's therapeutic efficacy against non-small cell lung cancer(NSCLC) by blocking autophagy with either a lysosomal protease inhibitor or MEK inhibitor.</div></front></TEI><affiliations><list><country><li>Australie</li><li>République populaire de Chine</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ren, Hui" sort="Ren, Hui" uniqKey="Ren H" first="Hui" last="Ren">Hui Ren</name></noRegion><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name><name sortKey="Chen, Tianjun" sort="Chen, Tianjun" uniqKey="Chen T" first="Tianjun" last="Chen">Tianjun Chen</name><name sortKey="Feng, Jing" sort="Feng, Jing" uniqKey="Feng J" first="Jing" last="Feng">Jing Feng</name><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><name sortKey="Liang, Yiqian" sort="Liang, Yiqian" uniqKey="Liang Y" first="Yiqian" last="Liang">Yiqian Liang</name><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name><name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name><name sortKey="Shi, Puyu" sort="Shi, Puyu" uniqKey="Shi P" first="Puyu" last="Shi">Puyu Shi</name><name sortKey="Thakur, Asmitananda" sort="Thakur, Asmitananda" uniqKey="Thakur A" first="Asmitananda" last="Thakur">Asmitananda Thakur</name><name sortKey="Wang, Ting" sort="Wang, Ting" uniqKey="Wang T" first="Ting" last="Wang">Ting Wang</name><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name><name sortKey="Yang, Tian" sort="Yang, Tian" uniqKey="Yang T" first="Tian" last="Yang">Tian Yang</name><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. 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